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Paracetamol 500mg + Domperidone 20mg – Paracetamol 500mg combined with Domperidone 20mg is prescribed to alleviate symptoms of migraine and other ailments accompanied by nausea/vomiting and fever/pain. Migraine is a type of neurological disorder that typically results in intense throbbing pain or a pulsating feeling, often experienced on one side of the head, as well as in the eyes, face, and neck. Symptoms may consist of feelings of nausea, vomiting, trouble speaking, numbness or tingling sensation, and sensitivity to light and sound.

How do Paracetamol 500mg + Domperidone 20mg Works?

Paracetamol + Domperidone is a blend of two medications: Domperidone and Paracetamol. Domperidone works by blocking specific receptors (such as dopamine and serotonin) in the brain’s vomiting center (chemoreceptor trigger zone – CTZ), thus preventing nausea and vomiting symptoms. It also serves as a prokinetic agent that enhances motility in the upper gastrointestinal tract and aids in reducing stomach emptying time. Paracetamol is a nonsteroidal anti-inflammatory drug (NSAID) that operates by inhibiting the action of a chemical messenger in the body called cyclo-oxygenase (COX) enzymes that produce another chemical called ‘prostaglandins’ (PG). Prostaglandins are generated at sites of injury, leading to pain and inflammation. Blocking COX enzymes diminishes the production of PGs, leading to decreased pain and inflammation at the site of injury or damage.

Uses of Paracetamol 500mg + Domperidone 20mg

Paracetamol 500mg + Domperidone 20mg is a combination medication commonly used for the relief of various symptoms related to pain, fever, and gastrointestinal issues. Here’s a detailed overview of its uses:

• Relieving Pain: Effective in relieving headaches, and aids in reducing muscle aches and pains from strain or injury. This also offers alleviation from toothaches and discomfort following dental treatments. It helps reduce the pain and discomfort of menstrual cramps.
• Reducing Fever: Paracetamol + Domperidone is commonly used for lowering fever caused by illnesses like the flu, common cold, and other infections.
• Relief from gastrointestinal issues: Domperidone is effective in controlling nausea and vomiting from different conditions like gastroenteritis, migraines, and motion sickness. It also alleviates signs of indigestion like bloating, stomach pain, and heartburn.
• Management of migraines: The mixture of this medication is successful in managing migraines by targeting both the pain (paracetamol) and the nausea/vomiting (domperidone) linked with migraines.
• Treating the Symptoms of Cold and Flu: Offers a wide range of symptom relief for cold and flu, such as fever, body aches, and nausea.

Side Effects of Paracetamol 500mg + Domperidone 20mg 

The following is a list of possible side effects that may occur from all constituting ingredients of Paracetamol, and Domperidone Tablets. 

• Nausea
• Vomiting
• Constipation
• Dryness in mouth
• Sleepiness
• Weakness
• Dizziness

Precautions of Paracetamol 500mg + Domperidone 20mg 

• A dry mouth can happen as a side effect of Paracetamol 500mg + Domperidone 20mg tablet. Regularly using mouthwashes, practicing proper oral care, drinking more water, and consuming sugar-free sweets could be beneficial.
• Let your doctor know if you are using any pain relief medication.
• Domperidone + Paracetamol may reduce the frequency and intensity of attacks but may not fully prevent them.

Guidelines to prevent a migraine occurrence:

• Eat your meals at consistent times daily.
• Stay away from severe lighting and extreme weather conditions.
• Stay away from loud music and places with a lot of noise.
• Refrain from consuming chocolates, cheese, processed food, alcohol, and smoking.
• Make sure to get adequate rest and steer clear of stressful situations.